Methemoglobin reductase activity in human erythrocytes under hypoxia conditions

Abstract

A kinetic mathematical model of erythrocyte metabolism involving O2- sensitive mechanisms of hemoglobin and methemoglobin reductase systems was developed to predict temporal changes in intracellular metabolites, reaction flows, and cellular energy in response to hypoxia. The work of two methemoglobin reductase systems was studied in silico experiments. It is shown that the obtained experimental data of the NADP(NAD)H-dependent methemoglobin reductase activity studies coincide with the simulation results.